If provided with antioxidants, our cells are equipped with the means to deal with oxidative stress, but ironically, if those cells don't have enough oxygen to do so, oxygen becomes a lot more harmful when all of a sudden a lot of it comes in, which has the effects of a backdraft. This is why, after ischemia e.g. because of a stroke, too sudden a re-perfusion of blood can cause injury. It's also why it's important to warm up before exercise.
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