Disclaimer: I'm not a doctor, these are just speculations. Glutamate is one of the most important, basic neurotransmitters that seems to be responsible for the intensity of the signal more than anything else. It's probably the neurotransmitter that most easily gets toxic in high concentrations, as it easily overstimulates neurons, causing inflammation. That's why glutamate antagonists like memantine are a good way to reset the nervous system to factory settings after a burnout. But these have some side effects, because glutamate is important for the nerves in the entire body: as the signals in the peripheral nervous system are also reduced in intensity, the body feels sluggish, anesthetized, causing dyspnea, ataxia and so on. So, memantine could be combined with D-aspartate, an amino acid that stimulates glutamatergic receptors, but does not cross the blood-brain barrier. This still allows the brain to restore, but everywhere else inflammation is returned to normal levels, including the blood vessels in the brain. So, this can still be a problem, as the blood vessels in the brain also regulate the intensity of their stimulation, and the blood vessels themselves are likely to get inflamed from a burnout. Therefore, D-aspartate use must be kept to a minimum, just high enough to negate side effects of memantine, lest it negates some of its positive effects as well.
Most of us probably have too much glutamate to be healthy, because glutamate is mostly useful for crises, and now that we are so safe in the modern world, our organism doesn't need to be perpetually in a state of high alert anymore: there's no panther around the corner waiting to pounce.
Moreover, evolution doesn't care as much about us staying fit as about procreation, and to achieve that goal we are put under a lot of strain: we are sprinting for it, like spermatozoids for the egg — which is not to say that we're obsessed with sex, but that we're obsessed with achieving things that will make it possible for our children to survive once we've had enough sex, and for them to be able to procreate themselves later on, like security and status etc. That's why there's a link between glutamate and testosterone: they intensify each other. Glutamate is the "yang" of neurotransmitters.
So, glutamate antagonism makes you more detached and therefore spiritual, while glutamate agonism and its resultant testosterone effect makes you more down-to-earth. This is a very delicate balance that shouldn't be taken lightly: we must not lose one in favor of the other.
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